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The research group of Michael Nothnagel focuses on statistical genetics, including genetic epidemiology, population genetics and forensic genetics. This includes theoretical and methodological work as well as data analysis in collaborative projects, with a focus on human data. Michael Nothnagel and his co-workers take advantage of growing genome-wide datasets from genotyping and next-generation sequencing (NGS) as well as of specialized forensic genetic markers. Besides others, his group has made important contributions to the identification of genetic factors implicated in different human diseases, theoretical insights into disease etiology, the elucidation of continental and worldwide phylogeographic patterns of human genetic diversity and the selection of most informative markers in forensic applications. Michael Nothnagel and his co-workers are involved in a number of national and international projects on statistical genetics.

Spatial frequency interpolation of human Y-haplogroup C3* (C-M217) around the Pacific Ocean

Selected publications

  1. Roewer L*, Nothnagel M*, Gusmão L, Gomes V, González M, Corach D, Sala A, Alechine E, Palha T, Santos N, Ribeiro-Dos-Santos A, Geppert M, Willuweit S, Nagy M, Zweynert S, Baeta M, Núñez C, Martínez-Jarreta B, González-Andrade F, Fagundes de Carvalho E, da Silva DA, Builes JJ, Turbón D, Lopez Parra AM, Arroyo-Pardo E, Toscanini U, Borjas L, Barletta C, Ewart E, Santos S, Krawczak M (2013). Continent-wide decoupling of Y-chromosomal genetic variation from language and geography in native South Americans. PLoS Genet, 9(4):e1003460. (* equal contribution) doi: 10.1371/journal.pgen.1003460
  2. Lemke JR, Lal D, Reinthaler EM, Steiner I, Nothnagel M, Alber M, Geider K, Laube B, Schwake M, Finsterwalder K, Franke A, Schilhabel M, Jähn JA, Muhle H, Boor R, Van Paesschen W, Caraballo R, Fejerman N, Weckhuysen S, De Jonghe P, Larsen J, Møller RS, Hjalgrim H, Addis L, Tang S, Hughes E, Pal DK, Veri K, Vaher U, Talvik T, Dimova P, Guerrero López R, Serratosa JM, Linnankivi T, Lehesjoki AE, Ruf S, Wolff M, Buerki S, Wohlrab G, Kroell J, Datta AN, Fiedler B, Kurlemann G, Kluger G, Hahn A, Haberlandt DE, Kutzer C, Sperner J, Becker F, Weber YG, Feucht M, Steinböck H, Neophythou B, Ronen GM, Gruber-Sedlmayr U, Geldner J, Harvey RJ, Hoffmann P, Herms S, Altmüller J, Toliat MR, Thiele H, Nürnberg P, Wilhelm C, Stephani U, Helbig I, Lerche H, Zimprich F, Neubauer BA, Biskup S, von Spiczak S (2013). Mutations in GRIN2A cause idiopathic focal epilepsy with rolandic spikes. Nat Genet 45(9):1067-72. doi: 10.1038/ng.2728
  3. Purps J*, Siegert S*, Willuweit S, Nagy M, Alves C, Salazar R, Angustia SMT, Santos LH, Anslinger K, Bayer B, Ayub Q, Wei W, Xue Y, Tyler-Smith C, Baeta Bafalluy M, Martínez-Jarreta B, Egyed B, Balitzki B, Tschumi S, Ballard D, Syndercombe Court D, Barrantes X, Bäßler G, Wiest T, Berger B, Niederstätter H, Parson W, Davis C, Budowle B, Burri H, Borer U, Koller C, Carvalho EF, Domingues PM, Takash Chamoun W, Coble MD, Hill CR, Corach D, Caputo M, D'Amato ME, Davison S, Decorte R, Larmuseau MHD, Ottoni C, Rickards O, Lu D, Jiang C, Dobosz T, Jonkisz A, Frank WE, Furac I, Gehrig C, Castella V, Grskovic B, Haas C, Wobst J, Hadzic G, Drobnic K, Honda K, Hou Y, Zhou D, Li Y, Hu S, Chen S, Immel UD, Lessig R, Jakovski Z, Ilievska T, Klann AE, Cano García C, de Knijff P, Kraaijenbrink T, Kondili A, Miniati P, Vouropoulou M, Kovacevic L, Marjanovic D, Lindner I, Mansour I, Al-Azem M, El Andari A, Marino M, Furfuro S, Locarno L, Martín P, Luque GM, Alonso A, Souto Miranda L, Moreira H, Mizuno N, Iwashima Y, Moura Neto RS, Nogueira TLS, Silva R, Nastainczyk-Wulf M, Edelmann J, Kohl M, Nie S, Wang X, Cheng B, Núñez C, Martínez de Pancorbo M, Olofsson JK, Morling N, Onofri V, Tagliabracchi A, Pamjav H, Volgyi A, Barany G, Pawlowski R, Maciejewska A, Pelotti S, Pepinski W, Abreu-Glowacka M, Phillips C, Cárdenas J, Rey-Gonzalez D, Salas A, Brisighelli F, Capelli C, Toscanini U, Piccinini A, Piglionica M, Baldassarra SL, Ploski R, Konarzewska M, Jastrzebska E, Robino C, Sajantila A, Palo JU, Guevara E, Salvador J, Corazon De Ungria M, Joseph Russell Rodriguez J, Schmidt U, Schlauderer N, Saukko P, Schneider PM, Sirker M, Shin KJ, Na Oh Y, Skitsa I, Ampati A, Smith TG, Solis de Calvit L, Stenzl V, Capal T, Tillmar A, Nilsson N, Turrina S, De Leo D, Verzeletti A, Cortellini V, Wetton JH, Gwynne GM, Jobling MA, Whittle MR, Sumita DR, Wolańska-Nowak P, Yong RYY, Krawczak M, Nothnagel M*, Roewer L* (2014). A global analysis of Y-chromosomal haplotype diversity for 23 STR loci. Forensic Sci Int Genet, 12:12-23. (* equal contribution) doi: 10.1016/j.fsigen.2014.04.008
  4. Siegert S, Roewer L, Nothnagel M (2015). Shannon's equivocation for forensic Y-STR marker selection. Forensic Sci Int Genet, 16C:216-225. doi: 10.1016/j.fsigen.2015.02.001
  5. Syrbe S, Hedrich UBS, Riesch E, Djémié T, Müller S, Møller RS, Maher B, Hernandez-Hernandez L, Synofzik M, Caglayan HS, Arslan M, Serratosa JM, Nothnagel M, May P, Krause R, Löffler H, Detert K, Dorn T, Vogt H, Krämer G, Schöls L, Mullis PE, Linnankivi T, Lehesjoki AE, Sterbova K, Craiu DC, Hoffman-Zacharska D, Korff CM, Weber YG, Steinlin M, Gallati S, Bertsche A, Bernhard MK, Merkenschlager A, Kiess K, EuroEPINOMICS RES consortium, Gonzalez M, Züchner S, Palotie A, Suls A, De Jonghe P, Helbig I, Biskup S, Wolff M, Maljevic S, Schüle R, Sisodiya SM, Weckhuysen S, Lerche H, Lemke JR (2015). Hyperexcitability or electrical silencing: de novo loss- or gain-of-function mutations in KCNA2 cause epileptic encephalopathy. Nat Genet, 47(4):393-9. doi:10.1038/ng.3239
  6. Siegert S, Wolf A, Cooper DN, Krawczak M*, Nothnagel M* (2015). Mutations causing complex disease may under certain circumstances be protective in an epidemiological sense. PLoS One, 10(7):e0132150. (* equal contribution) doi: 10.1371/journal.pone.0132150
  7. Diegoli TM, Rohde H, Borowski S, Krawczak M, Coble MD, Nothnagel M (2016). Genetic mapping of 15 human X chromosomal forensic short tandem repeat (STR) loci by means of multi-core parallelization. Forensic Sci Int Genet, 25:39-44. doi: 10.1016/j.fsigen.2016.07.004.
  8. Nothnagel M, Fan G, Guo F, He Y, Hou Y, Hu S, Huang J, Jiang X, Kim W, Kim K, Li C, Li H, Li L, Li S, Li Z, Liang W, Liu C, Lu D, Luo H, Nie S, Shi M, Sun H, Tang J, Wang L, Wang C, Wang D, Wen S, Wu H, Wu W, Xing J, Yan J, Yan S, Yao H, Ye Y, Yun L, Zeng Z, Zha L, Zhang S, ZhengX, Willuweit S, Roewer L. Revisiting the male genetic landscape of China: a multi-center study of almost 38,000 Y-STR haplotypes. Hum Genet, 136(5):485-497. doi: 10.1007/s00439-017-1759-x.
  9. Heilmann-Heimbach S, Herold C, Hochfeld L, Hillmer A, Nyholt D, Hecker J, Javed A, Chew E, Pechlivanis S, Drichel D, Heng XT, del Rosario R, Fier H, Paus R, Rueedi R, Galesloot T, Moebus S, Anhalt T, Prabhakar S, Li R, Kanoni S, Papanikolaou G, Kutalik Z, Deloukas P, Philpott M, Waeber G, Spector T, Vollenweider P, Kiemeney L, Dedoussis G, Richards JB, Nothnagel M, Martin N, Becker T, Hinds D, Nöthen M (2017). Meta-analysis identifies novel risk loci and yields systematic insights into the biology of male-pattern baldness. Nature Comm, 8:14694. doi: 10.1038/ncomms14694
  10. Kanoungi G, Nothnagel M (2018). Pathway-induced allelic spectra of diseases. Hum Genet, Epub ahead of print. doi: 10.1007/s00439-018-1872-5